Compartmental analysis of dynamic nuclear medicine data: regularization procedure and application to physiology

DOI10.1080/17415977.2018.1512603zbMATH Open1462.92034arXiv1608.01825OpenAlexW3100798587MaRDI QIDQ4990744FDOQ4990744

Authors: Fabrice Delbary, Sara Garbarino 

Publication date: 31 May 2021

Published in: Inverse Problems in Science and Engineering (Search for Journal in Brave)

Abstract: Compartmental models based on tracer mass balance are extensively used in clinical and pre-clinical nuclear medicine in order to obtain quantitative information on tracer metabolism in the biological tissue. This paper is the second of a series of two that deal with the problem of tracer coefficient estimation via compartmental modelling in an inverse problem framework. While the previous work was devoted to the discussion of identifiability issues for 2, 3 and n-dimension compartmental systems, here we discuss the problem of numerically determining the tracer coefficients by means of a general regularized Multivariate Gauss Newton scheme. In this paper, applications concerning cerebral, hepatic and renal functions are considered, involving experimental measurements on FDG-PET data on different set of murine models.

Full work available at URL: https://arxiv.org/abs/1608.01825

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zbMATH Keywords

Gauss-Newton methodcompartmental analysisnuclear medicine data

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biomedical imaging and signal processing (92C55)

Cites Work

• Generalized Cross-Validation as a Method for Choosing a Good Ridge Parameter
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• Estimate of FDG excretion by means of compartmental analysis and ant colony optimization of nuclear medicine data
• Compartmental analysis of dynamic nuclear medicine data: models and identifiability
• A physiology-based parametric imaging method for FDG–PET data

Cited In (4)

• Computational Science and Its Applications – ICCSA 2004
• Global Compartmental Pharmacokinetic Models for Spatiotemporal SPECT and PET Imaging
• Multivariate regularized Newton and Levenberg-Marquardt methods: a comparison on synthetic data of tumor hypoxia in a kinetic framework
• Title not available (Why is that?)

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