A physiology-based parametric imaging method for FDG-PET data
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Publication:4601431
DOI10.1088/1361-6420/AA9544zbMATH Open1394.92076arXiv1702.06067OpenAlexW3106272069MaRDI QIDQ4601431FDOQ4601431
Authors: Mara Scussolini, Sara Garbarino, Gianmario Sambuceti, Michele Piana, Giacomo Caviglia 
Publication date: 16 January 2018
Published in: Inverse Problems (Search for Journal in Brave)
Abstract: Parametric imaging is a compartmental approach that processes nuclear imaging data to estimate the spatial distribution of the kinetic parameters governing tracer flow. The present paper proposes a novel and efficient computational method for parametric imaging which is potentially applicable to several compartmental models of diverse complexity and which is effective in the determination of the parametric maps of all kinetic coefficients. We consider applications to [{18}F]-fluorodeoxyglucose Positron Emission Tomography (FDG-PET) data and analyze the two-compartment catenary model describing the standard FDG metabolization by an homogeneous tissue and the three-compartment non-catenary model representing the renal physiology. We show uniqueness theorems for both models. The proposed imaging method starts from the reconstructed FDG-PET images of tracer concentration and preliminarily applies image processing algorithms for noise reduction and image segmentation. The optimization procedure solves pixelwise the non-linear inverse problem of determining the kinetic parameters from dynamic concentration data through a regularized Gauss-Newton iterative algorithm. The reliability of the method is validated against synthetic data, for the two-compartment system, and experimental real data of murine models, for the renal three-compartment system.
Full work available at URL: https://arxiv.org/abs/1702.06067
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- scientific article; zbMATH DE number 1254056
Biomedical imaging and signal processing (92C55) Image processing (compression, reconstruction, etc.) in information and communication theory (94A08) Inverse problems involving ordinary differential equations (34A55) Numerical solution of inverse problems involving ordinary differential equations (65L09)
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