Conditional inference for restricted randomization designs

DOI10.1214/AOS/1176350952MaRDI QIDQ1106579zbMATH OpenOpenAlexFDO

Authors Robert T. Smythe

Publication date 1988

Published in The Annals of Statistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1214/aos/1176350952

zbMATH Keywords

asymptotic null distributionclinical trialconditional inferenceGaussian limit distributionlocal limit theoremspermutation testsrestricted randomization rules

Mathematics Subject Classification ID

Central limit and other weak theorems (60F05) Asymptotic distribution theory in statistics (62E20) Nonparametric hypothesis testing (62G10) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Review text

In a clinical trial to compare two treatments, suppose that patients are assigned to treatment according to a certain class of restricted randomization rules. Conditional on the difference in numbers between the two treatment groups, the asymptotic null distribution of a class of permutation tests is shown to be Gaussian.

Recommendations

• K-treatment comparisons with restricted randomization rules in clinical trials
• Significance tests with restricted randomization design
• Constructing exact significance tests with restricted randomization rules
• Nonparametric Tests Under Restricted Treatment-Assignment Rules
• Non-parametric inference for balanced randomization designs

Cited in

(12)

• K-treatment comparisons with restricted randomization rules in clinical trials
• Significance tests with restricted randomization design
• Two-sample post-stratified or subgroup analysis with restricted randomization rules
• Sequential Monitoring of Conditional Randomization Tests: Generalized Biased Coin Designs
• Stopping Rules in Balanced Allocation Problems: Exact and Asymptotic Distributions
• scientific article; zbMATH DE number 3938346 (Why is no real title available?)
• Constructing exact significance tests with restricted randomization rules
• Interval estimation with restricted randomization rules
• Bias properties and nonparametric inference for truncated binomial randomization
• Sequential monitoring with conditional randomization tests
• A Comparison of Conditional and Unconditional Randomization Tests for Highly Stratified Designs
• Hadamard randomization: a valid restriction of random permuted blocks

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