Convex Optimization of the Basic Reproduction Number

DOI10.1109/TAC.2022.3212012MaRDI QIDQ6080243zbMATH OpenOpenAlexFDO

Authors Kevin Smith, Francesco Bullo

Publication date 2 October 2023

Published in IEEE Transactions on Automatic Control (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2109.07643

zbMATH Keywords

compartmental modelsconvex optimizationepidemicsgeometric programmingoptimal resource allocation

Mathematics Subject Classification ID

Systems theory; control (93-XX)

Abstract: The basic reproduction number $R_0$ is a fundamental quantity in epidemiological modeling, reflecting the typical number of secondary infections that arise from a single infected individual. While $R_0$ is widely known to scientists, policymakers, and the general public, it has received comparatively little attention in the controls community. This note provides two novel characterizations of $R_0$: a stability characterization and a geometric program characterization. The geometric program characterization allows us to write $R_0$-constrained and budget-constrained optimal resource allocation problems as geometric programs, which are easily transformed into convex optimization problems. We apply these programs to allocating vaccines and antidotes in numerical examples, finding that targeting $R_0$ instead of the spectral abscissa of the Jacobian matrix (a common target in the controls literature) leads to qualitatively different solutions.

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(2)

• Bounding the Optimal Rate of the ICSI and ICCSI problem
• Analysis, state estimation, and control for the networked competitive multi-virus SIR model

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