Covariance adjustment for batch effect in gene expression data

DOI10.1002/SIM.6157MaRDI QIDQ6929734zbMATH OpenFDO

Authors Jung Lee Ae, Kevin K. Dobbin, Jeongyoun Ahn

Publication date 16 September 2025

Published in Statistics in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/SIM.6157

zbMATH Keywords

batch effectfactor modelgene expressionhigh-dimensional covariance estimation

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• Adaptive thresholding for sparse covariance matrix estimation
• Adjusting batch effects in microarray expression data using empirical Bayes methods
• Covariance regularization by thresholding
• Distance-Weighted Discrimination
• Efficient quadratic regularization for expression arrays
• Frozen robust multiarray analysis (fRMA)
• High dimensional covariance matrix estimation using a factor model
• High-dimensional sparse factor modeling: applications in gene expression genomics
• On testing the significance of sets of genes
• Testing the equality of several covariance matrices with fewer observations than the dimension

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