Data-Driven Modeling and Control of Complex Dynamical Systems Arising in Renal Anemia Therapy

DOI10.1007/978-3-031-11818-0_21MaRDI QIDQ6095013zbMATH OpenOpenAlexFDO

Authors Doris H. Fuertinger, P. Kotanko, Luca Mechelli, S. Volkwein

Publication date 15 September 2023

Published in Mathematics in Industry (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2106.11733

Mathematics Subject Classification ID

Numerical analysis (65-XX)

Abstract: This project is based on a mathematical model of erythropoiesis for anemia, which consists of five hyperbolic population equations describing the production of red blood cells under treatment with epoetin-alfa (EPO). Extended dynamic mode decomposition (EDMD) is utilized to approximate the non-linear dynamical systems by linear ones. This allows for efficient and reliable strategies based on a combination of EDMD and model predictive control (MPC), which produces results comparable with the one obtained in past publications for the original model.

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Cites work

• A data-driven approximation of the koopman operator: extending dynamic mode decomposition
• A model of erythropoiesis in adults with sufficient iron availability
• scientific article; zbMATH DE number 6678650 (Why is no real title available?)
• Linear predictors for nonlinear dynamical systems: Koopman operator meets model predictive control
• Nonlinear model predictive control. Theory and algorithms
• Optimal EPO dosing in hemodialysis patients using a non-linear model predictive control approach
• Optimization with PDE Constraints

Cited in

(3)

• Online identification and control of PDEs via reinforcement learning methods
• A POD approach to identify and control PDEs online through state dependent Riccati equations
• A PINN approach for the online identification and control of unknown PDEs

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