Data-driven selection and parameter estimation for DNA methylation mathematical models

DOI10.1016/J.JTBI.2019.01.012MaRDI QIDQ1730118zbMATH OpenOpenAlexWikidataFDO

Authors K. Larson, Loukas Zagkos, Mark Mc Auley, Nikos I. Kavallaris, Anastasios Matzavinos, J. A. Roberts

Publication date 11 March 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL http://hdl.handle.net/10034/621823

zbMATH Keywords

model selectionparameter estimationDNA methylationCpG dyadsgene promoter

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Biochemistry, molecular biology (92C40) Software, source code, etc. for problems pertaining to biology (92-04)

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Cites work

• A dynamic multi-compartmental model of DNA methylation with demonstrable predictive value in hematological malignancies
• Bayesian reasoning and machine learning.
• Mathematical models of DNA methylation dynamics: implications for health and ageing
• \(\Pi\)4U: a high performance computing framework for Bayesian uncertainty quantification of complex models

Cited in

(6)

• Exponential dynamics of DNA methylation with age
• A Bayesian framework to estimate fluid and material parameters in micro-swimmer models
• A stochastic model for the formation of spatial methylation patterns
• Modeling dependence in methylation patterns with application to ovarian carcinomas
• Feature selection using logistic regression in case-control DNA methylation data of Parkinson's disease: a comparative study
• Mathematical models of DNA methylation dynamics: implications for health and ageing

Describes a project that uses

Uses Software

• Pi4U

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