Dynamic analysis of a tumor-immune system under Allee effect

DOI10.1155/2020/4892938MaRDI QIDQ2007336zbMATH OpenOpenAlexFDO

Authors Chunmei Zeng, Shao-juan Ma

Publication date 13 October 2020

Published in Mathematical Problems in Engineering (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2020/4892938

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Stochastic ordinary differential equations (aspects of stochastic analysis) (60H10) Medical applications (general) (92C50) Medical epidemiology (92C60)

Review text

Summary: In this paper, we develop a definite tumor-immune model considering Allee effect. The deterministic model is studied qualitatively by mathematical analysis method, including the positivity, boundness, and local stability of the solution. In addition, we explore the effect of random factors on the transition of the tumor-immune system from a stable coexistence equilibrium point to a stable tumor-free equilibrium point. Based on the method of stochastic averaging, we obtain the expressions of the steady-state probability density and the mean first-passage time. And we find that the Allee effect has the greatest impact on the number of cells in the system when the Allee threshold value is within a certain range; the intensity of random factors could affect the likelihood of the system crossing from the coexistence equilibrium to the tumor-free equilibrium.

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Cites work

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Cited in

(10)

• Is the Allee effect relevant in cancer evolution and therapy?
• Co-dimension two bifurcations analysis of a delayed tumor model with Allee effect
• On a 2D model of avascular tumor with weak Allee effect
• An Allee threshold model for a Glioblastoma (GB)-immune system (IS) interaction with fuzzy initial values
• Influences of Allee effects in the spreading of malignant tumours
• Dynamical analysis of a melanoma model with immune response
• A mathematical model for treatment of papillary thyroid cancer using the Allee effect
• STOCHASTIC DYNAMICS BETWEEN THE IMMUNE SYSTEM AND CANCER CELLS WITH ALLEE EFFECT AND IMMUNOTHERAPY
• Bayesian inference on the Allee effect in cancer cell line populations using time-lapse microscopy images
• Mathematical modeling of Allee effects in tumor dynamics: insights into chemotherapy and immunotherapy optimization

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