Efficient control of transient wave forms to prevent spreading depolarizations

DOI10.1016/J.JTBI.2007.11.019MaRDI QIDQ1788641zbMATH OpenOpenAlexWikidataFDO

Authors Markus A. Dahlem, Friedrich Martin Schneider, Eckehard Schöll

Publication date 8 October 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0705.3398

zbMATH Keywords

controlnonlinear dynamical systemexcitability

Mathematics Subject Classification ID

Medical applications (general) (92C50) Neural biology (92C20) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Abstract: In various neurological disorders spatio-temporal excitation patterns constitute examples of excitable behavior emerging from pathological pathways. During migraine, seizure, and stroke an initially localized pathological state can temporarily spread indicating a transition from non-excitable to excitable behavior. We investigate these transient wave forms in the generic FitzHugh-Nagumo (FHN) system of excitable media. Our goal is to define an efficient control minimizing the volume of invaded tissue. The general point of such a therapeutic optimization is how to apply control theory in the framework of structures in differential geometry by regarding parameter plane M of the FHN system as a differential manifold endowed with a metric. We suggest to equip M with a metric given by pharmacokinetic-pharmacodynamic models of drug receptor interaction.

Recommendations

• Control of sub-excitable waves in neural networks by nonlocal coupling
• Central nervous tissue: an excitable medium. A study using the retinal spreading depression as a tool
• Control of spiral waves in excitable media
• Two-dimensional wave patterns of spreading depolarization: retracting, re-entrant, and stationary waves
• Stabilization of inhomogeneous patterns in a diffusion-reaction system under structural and parametric uncertainties

Cites work

• Elements of applied bifurcation theory
• Kinematical theory of spiral waves in excitable media: Comparison with numerical simulations
• Reaction-diffusion waves in neuronal tissue and the window of cortical excitability
• Varieties of spiral wave behavior: An experimentalist’s approach to the theory of excitable media

Cited in

(7)

• On a Fitzhugh-Nagumo type model for the pulse-like jasmonate defense response in plants
• Two-dimensional wave patterns of spreading depolarization: retracting, re-entrant, and stationary waves
• Analytical and Simulation Results for the Stochastic Spatial Fitzhugh-Nagumo Model Neuron
• Control of sub-excitable waves in neural networks by nonlocal coupling
• Stochastic modeling of spreading cortical depression
• Transient localized wave patterns and their application to migraine
• Role of coupling delay in oscillatory activity in autonomous networks of excitable neurons with dissipation

This page was built for publication: Efficient control of transient wave forms to prevent spreading depolarizations

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1788641)