Elucidation of T cell signalling models

DOI10.1016/J.JTBI.2009.10.017MaRDI QIDQ1629053zbMATH OpenOpenAlexWikidataFDO

Authors Nick D. L. Owens, Jon Timmis, Andrew Greensted, Andy Tyrrell

Publication date 11 December 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2009.10.017

zbMATH Keywords

CD8, SHP1, ERKcontinuous time Markov chainkinetic proofreadingnegative feedbackstochastic modellingT cell tunability

Mathematics Subject Classification ID

Cell biology (92C37) Biochemistry, molecular biology (92C40) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• Coreceptor CD8-driven modulation of T cell antigen receptor specificity
• Expokit
• Markov Chains
• Nineteen Dubious Ways to Compute the Exponential of a Matrix, Twenty-Five Years Later
• Numerical Methods in Markov Chain Modeling
• Stochastic effects and bistability in T cell receptor signaling

Cited in

(11)

• Stochastic effects and bistability in T cell receptor signaling
• A theory of coalescence of signaling receptor clusters in immune cells
• Coreceptor CD8-driven modulation of T cell antigen receptor specificity
• Modeling deuterated glucose labeling of T-lymphocytes
• Quantifying the strength of ligand antagonism in TCR triggering
• Kinetic proofreading in receptor-mediated transduction of cellular signals: receptor aggregation, partially activated receptors, and cytosolic messengers
• T cell sensitivity and specificity-kinetic proofreading revisited
• The case for absolute ligand discrimination: modeling information processing and decision by immune T cells
• Structural and functional robustness of the adaptive-sorting signaling network
• The receptor density algorithm
• scientific article; zbMATH DE number 2193316 (Why is no real title available?)

Describes a project that uses

Uses Software

• Expokit

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