Stochastic modelling of T-cell activation
From MaRDI portal
Publication:2512923
Central limit and other weak theorems (60F05) Large deviations (60F10) Functional limit theorems; invariance principles (60F17) Interacting random processes; statistical mechanics type models; percolation theory (60K35) Processes in random environments (60K37) Applications of statistics to biology and medical sciences; meta analysis (62P10) Cell biology (92C37) Medical applications (general) (92C50)
Abstract: We investigate a special part of the human immune system, namely the activation of T-Cells, using stochastic tools, especially sharp large deviation results. T-Cells have to distinguish reliably between foreign and self peptides which are both presented to them by antigen presenting cells. Our work is based on a model studied by Zint, Baake, and den Hollander, and originally proposed by van den Berg, Rand, and Burroughs. We are able to dispense with some restrictive distribution assumptions that were used previously, i.e. we establish a higher robustness of the model. A central issue is the analysis of two new perspectives to the scenario (two different quenched systems) in detail. This means that we do not only analyse the total probability of a T-Cell activation (the annealed case) but also consider the probability of an activation of one certain T-Cell type and the probability of a T-Cell activation by a certain antigen presenting cell (the quenched cases). Finally, we see analytically that the probability of T-Cell activation increases with the number of presented foreign peptides in all three cases.
Recommendations
- A Stochastic Model of the Effector T Cell Lifecycle
- A stochastic model of cytotoxic T cell responses
- Stochastic approximation to the T cell mediated specific response of the immune system
- Stochastic effects and bistability in T cell receptor signaling
- Rare event simulation for T-cell activation
- Stochastic modeling of t cell receptor \(\gamma\) gene rearrangement
- Stochastic effects of the tumor‐T cell immune model
- Stochastic Modeling of Naïve T Cell Homeostasis for Competing Clonotypes via the Master Equation
- Some stochastic models in immunology
Cites work
- Foreignness as a matter of degree: the relative immunogenicity of peptide/MHC ligands
- How T-cells use large deviations to recognize foreign antigens
- scientific article; zbMATH DE number 1713116 (Why is no real title available?)
- scientific article; zbMATH DE number 1834045 (Why is no real title available?)
- Large deviations
- Large deviations techniques and applications.
- On Deviations of the Sample Mean
- Quantifying the strength of ligand antagonism in TCR triggering
- Rare event simulation for T-cell activation
- Strong large deviation and local limit theorems
- Thymic Presentation of Autoantigens and the Efficiency of Negative Selection
Cited in
(16)- Rare event simulation for T-cell activation
- Elucidation of T cell signalling models
- Stochastic niche structure and diversity maintenance in the T cell repertoire
- Stochastic modeling of t cell receptor \(\gamma\) gene rearrangement
- Modeling deuterated glucose labeling of T-lymphocytes
- The impact of multiple T cell\,-\,APC encounters and the role of anergy
- A mathematical model for a T cell fate decision algorithm during immune response
- Stochastic approximation to the T cell mediated specific response of the immune system
- Stochastic Modeling of Naïve T Cell Homeostasis for Competing Clonotypes via the Master Equation
- An analysis of \textit{early-stage} IL-2 capture times in populations of T cells diffusively interacting in a confined environment
- scientific article; zbMATH DE number 3932834 (Why is no real title available?)
- scientific article; zbMATH DE number 2149591 (Why is no real title available?)
- Detecting T cell activation using a varying dimension Bayesian model
- Thymic selection of T cells as diffusion with intermittent traps
- Agent-based modeling of the context dependency in T cell recognition
- How T-cells use large deviations to recognize foreign antigens
This page was built for publication: Stochastic modelling of T-cell activation
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2512923)
