Stochastic approximation to the T cell mediated specific response of the immune system
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Publication:285145
DOI10.1016/J.JTBI.2011.11.003zbMATH Open1336.92021arXiv1104.5449OpenAlexW1997360289WikidataQ51494637 ScholiaQ51494637MaRDI QIDQ285145FDOQ285145
Kalet León, Roberto Mulet, Nuris Figueroa-Morales
Publication date: 19 May 2016
Published in: Journal of Theoretical Biology (Search for Journal in Brave)
Abstract: We develop a stochastic model to study the specific response of the immune system. The model is based on the dynamical interaction between Regulatory and Effector CD4+ T cells in the presence of Antigen Presenting Cells inside a lymphatic node. At a mean field level the model predicts the existence of different regimes where active, tolerant, or cyclic immune responses are possible. To study the model beyond mean field and to understand the specific responses of the immune system we use the Linear Noise Approximation and show that fluctuations due to finite size effects may strongly alter the mean field scenario. Moreover, it was found the existence of a certain characteristic frequency for the fluctuations. All the analytical predictions were compared with simulations using the Gillespie's algorithm.
Full work available at URL: https://arxiv.org/abs/1104.5449
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Cited In (10)
- A Stochastic Model of the Effector T Cell Lifecycle
- On the role of intrinsic noise on the response of the p53-Mdm2 module
- Stochastic modelling of T-cell activation
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- An analysis of \textit{early-stage} IL-2 capture times in populations of T cells diffusively interacting in a confined environment
- Stochastic niche structure and diversity maintenance in the T cell repertoire
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- Stochastic Modeling of Naïve T Cell Homeostasis for Competing Clonotypes via the Master Equation
- Mathematical models for immunology: current state of the art and future research directions
- Dynamic Regulation of T Cell Activation by Coupled Feedforward Loops
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