Amplified biochemical oscillations in cellular systems
From MaRDI portal
Publication:2641405
Abstract: We describe a mechanism for pronounced biochemical oscillations, relevant to microscopic systems, such as the intracellular environment. This mechanism operates for reaction schemes which, when modeled using deterministic rate equations, fail to exhibit oscillations for any values of rate constants. The mechanism relies on amplification of the underlying stochasticity of reaction kinetics within a narrow window of frequencies. This amplification allows fluctuations to beat the central limit theorem, having a dominant effect even though the number of molecules in the system is relatively large. The mechanism is quantitatively studied within simple models of self-regulatory gene expression, and glycolytic oscillations.
Recommendations
- scientific article; zbMATH DE number 4012388
- Analysis of multimodal stochastic oscillations in a biochemical reaction model
- Concentration fluctuations in a mesoscopic oscillating chemical reaction system
- From simple to complex oscillatory behavior in metabolic and genetic control networks
- Stochastic coherence in an oscillatory gene circuit model
Cites work
- Computational cell biology
- scientific article; zbMATH DE number 3954718 (Why is no real title available?)
- scientific article; zbMATH DE number 3773010 (Why is no real title available?)
- scientific article; zbMATH DE number 3806623 (Why is no real title available?)
- scientific article; zbMATH DE number 819507 (Why is no real title available?)
- Mathematical physiology
- Modelling Biological Populations in Space and Time
Cited in
(20)- Deterministic and stochastic aspects of VEGF-A production and the cooperative behavior of tumoral cell colony
- Role of transcriptional bursts in cellular oscillations
- Signatures of nonlinearity in single cell noise-induced oscillations
- Oscillating microbial dynamics driven by small populations, limited nutrient supply and high death rates
- Deterministic and stochastic analysis for different types of regulations in the spontaneous emergence of cell polarity
- The relative contribution of direct and environmental transmission routes in stochastic avian flu epidemic recurrence: an approximate analysis
- Comparison of deterministic and stochastic regime in a model for Cdc42 oscillations in fission yeast
- Hybrid semantics for Bio-PEPA
- Detecting limit cycles in stochastic time series
- Stochastic approximation to the T cell mediated specific response of the immune system
- Approximation and inference methods for stochastic biochemical kinetics -- a tutorial review
- Macroscopically observable probability currents in finite populations
- On the role of intrinsic noise on the response of the p53-Mdm2 module
- The linear response of a glycolytic oscillator, driven by a multiplicative colored noise
- scientific article; zbMATH DE number 123372 (Why is no real title available?)
- Finite-size and correlation-induced effects in mean-field dynamics
- Exact power spectrum in a minimal hybrid model of stochastic gene expression oscillations
- Sustained oscillations for density dependent Markov processes
- On the molecular mechanisms driving pain perception and emergent collective behaviors
- Markovian dynamics on complex reaction networks
This page was built for publication: Amplified biochemical oscillations in cellular systems
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2641405)
