Role of transcriptional bursts in cellular oscillations

DOI10.1016/J.JTBI.2017.05.029zbMATH Open1381.92021arXiv1701.09028OpenAlexW2585633881WikidataQ47828195 ScholiaQ47828195MaRDI QIDQ1702263FDOQ1702263

Authors: N. Almeira, Sebastián Risau-Gusman 

Publication date: 28 February 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: Genetic oscillators are present in the cells of many organisms and control several biological processes. The common feature of such oscillators is the presence of a protein which represses the transcription of its own gene. Recently, it has been shown that for many genes transcription is not a continuous process, but that it proceeds in bursts. We study here the relationship between bursty transcription and the robustness of protein oscillations. We concentrate on the temporal profile of mRNA production by studying regimes where this profile changes but the amount of mRNA produced is kept fixed. For systems with different degrees of cooperativity we show that in general bursts are associated with more robust oscillations, but when they are too short and intense they can have the opposite effect. In other words, we show that, in terms of the regularity of the oscillations generated, there is an optimal value for the intensity of the bursts.

Full work available at URL: https://arxiv.org/abs/1701.09028

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zbMATH Keywords

mathematical modelingstochastic gene expressiongenetic oscillatorstranscription bursts

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Biological rhythms and synchronization (92B25) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Mathematical biology. Vol. 1: An introduction.
• The Quasi-Steady-State Assumption: A Case Study in Perturbation
• Amplified biochemical oscillations in cellular systems
• Circadian rhythms and molecular noise
• Title not available (Why is that?)

Cited In (1)

• Optimisation of gene expression noise for cellular persistence against lethal events

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