Emax model
| deterministic model | dimensional model | mathematical model | nonlinear model | static model |
Available identifiers
The Emax model in its non-cooperative form is a pharmacodynamic dose–response model that describes how drug effect increases with concentration in a simple hyperbolic manner. It assumes no cooperativity in the system, meaning the Hill coefficient is fixed at one, producing a non-sigmoidal saturation curve. The model is characterized by a maximal achievable effect and the concentration that produces half of this maximum, offering intuitive measures of drug efficacy and potency. As the n = 1 specialization of the Hill dose-response model, it represents the simplest form of saturable concentration–effect behavior. This non-cooperative Emax model is widely used in pharmacology, toxicology, and pharmacokinetic–pharmacodynamic analyses when dose–response relationships do not exhibit sigmoidal characteristics.
Contained entities
| Emax equation | |
| represents observed response | |
| represents maximal response | |
| represents drug concentration | |
| represents half maximal effective concentration | |
Computational tasks
nonlinear parameter estimation (Emax model)
References
| Pharmacodynamic principles and the time course of immediate drug effects | (review) |
Further links
| Item | Property |
|---|---|
| dose-response analysis | modelled by |
| Hill model (dose-response) | specialized by |
This page was built for model: Emax model
