Evaluating futility of a binary clinical endpoint using early read-outs

DOI10.1002/SIM.8366MaRDI QIDQ6627259zbMATH OpenFDO

Authors Stijn Vansteelandt, Filip De Ridder

Publication date 29 October 2024

Published in Statistics in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/SIM.8366

zbMATH Keywords

biomarkersconditional powerfutilityinterim analysis

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• An expected power approach for the assessment of composite endpoints and their components
• Bayesian Approaches to Randomized Trials
• Group Sequential Tests for Delayed Responses (with discussion)
• Including long- and short-term data in blinded sample size recalculation for binary endpoints
• Interim analysis incorporating short- and long-term binary endpoints
• Simple and Effective Confidence Intervals for Proportions and Differences of Proportions Result from Adding Two Successes and Two Failures
• Statistical monitoring of clinical trials. A unified approach.
• Stochastically curtailed tests in long–term clinical trials

Cited in

(2)

• Predicting outcomes of phase III oncology trials with Bayesian mediation modeling of tumor response
• Optimal Bayesian predictive probability for delayed response in single-arm clinical trials with binary efficacy outcome

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