Statistical monitoring of clinical trials. A unified approach.

DOI10.1007/978-0-387-44970-8zbMath1121.62098OpenAlexW3128528895MaRDI QIDQ2505454

Janet Turk Wittes, Michael A. Proschan, K. K. Gordon Lan

Publication date: 4 October 2006

Published in: Statistics for Biology and Health (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/978-0-387-44970-8

zbMATH Keywords

clinical trials\(B\)-value approachinterim analyses

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Brownian motion (60J65) Research exposition (monographs, survey articles) pertaining to statistics (62-02) Estimation in survival analysis and censored data (62N02) Testing in survival analysis and censored data (62N03)

Related Items

Most powerful test sequences with early stopping options ⋮ Bayesian designs and the control of frequentist characteristics: A practical solution ⋮ Design and monitoring of multi‐arm multi‐stage clinical trials ⋮ Estimation of conditional power for cluster‐randomized trials with interval‐censored endpoints ⋮ A Note on Familywise Error Rate for a Primary and Secondary Endpoint ⋮ Sample size optimization and initial allocation of the significance levels in group sequential trials with multiple endpoints ⋮ A unified framework for weighted parametric group sequential design ⋮ Group sequential tests: beyond exponential family models ⋮ Asymptotic properties of maximum likelihood estimators with sample size recalculation ⋮ Sample size re-estimation for confirmatory two-stage flexible multi-arm trial with normal outcomes ⋮ Approximating probabilities of correlated events ⋮ Robust adaptive incorporation of historical control data in a randomized trial of external cooling to treat septic shock ⋮ Optional stopping with Bayes factors: a categorization and extension of folklore results, with an application to invariant situations ⋮ Inference in Targeted Group‐Sequential Covariate‐Adjusted Randomized Clinical Trials ⋮ Operating Characteristics for Group Sequential Trials Monitored Under Fractional Brownian Motion ⋮ Sequential monitoring of response-adaptive randomized clinical trials ⋮ Continuous versus group sequential analysis for post-market drug and vaccine safety surveillance ⋮ Sequential detection of a steady state ⋮ Sequential monitoring of response-adaptive randomized clinical trials with sample size re-estimation ⋮ Inference of non-centrality parameter of a truncated non-central chi-squared distribution ⋮ Refined critical boundary with enhanced statistical power for non-directional two-sided tests in group sequential designs with multiple endpoints ⋮ Repeated Confidence Intervals Under Fractional Brownian Motion in Long-Term Clinical Trials ⋮ Group sequential BH and its adaptive versions controlling the FDR ⋮ A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks ⋮ Interim analysis of clinical trials based on urn models ⋮ An Introduction to Practical Sequential Inferences via Single-Arm Binary Response Studies Using the binseqtest R Package

Uses Software

• R

This page was built for publication: Statistical monitoring of clinical trials. A unified approach.