frailtypack
The following several classes of frailty models using a penalized likelihood estimation on the hazard function but also a parametric estimation can be fit using this R package: 1) A shared frailty model (with gamma or log-normal frailty distribution) and Cox proportional hazard model. Clustered and recurrent survival times can be studied. 2) Additive frailty models for proportional hazard models with two correlated random effects (intercept random effect with random slope). 3) Nested frailty models for hierarchically clustered data (with 2 levels of clustering) by including two iid gamma random effects. 4) Joint frailty models in the context of the joint modelling for recurrent events with terminal event for clustered data or not. A joint frailty model for two semi-competing risks and clustered data is also proposed. 5) Joint general frailty models in the context of the joint modelling for recurrent events with terminal event data with two independent frailty terms. 6) Joint Nested frailty models in the context of the joint modelling for recurrent events with terminal event, for hierarchically clustered data (with two levels of clustering) by including two iid gamma random effects. 7) Multivariate joint frailty models for two types of recurrent events and a terminal event. 8) Joint models for longitudinal data and a terminal event. 9) Trivariate joint models for longitudinal data, recurrent events and a terminal event. 10) Joint frailty models for the validation of surrogate endpoints in multiple randomized clinical trials with failure-time and/or longitudinal endpoints with the possibility to use a mediation analysis model. 11) Conditional and Marginal two-part joint models for longitudinal semicontinuous data and a terminal event. 12) Joint frailty-copula models for the validation of surrogate endpoints in multiple randomized clinical trials with failure-time endpoints. 13) Generalized shared and joint frailty models for recurrent and terminal events. Proportional hazards (PH), additive hazard (AH), proportional odds (PO) and probit models are available in a fully parametric framework. For PH and AH models, it is possible to consider type-varying coefficients and flexible semiparametric hazard function. Prediction values are available (for a terminal event or for a new recurrent event). Left-truncated (not for Joint model), right-censored data, interval-censored data (only for Cox proportional hazard and shared frailty model) and strata are allowed. In each model, the random effects have the gamma or normal distribution. Now, you can also consider time-varying covariates effects in Cox, shared and joint frailty models (1-5). The package includes concordance measures for Cox proportional hazards models and for shared frailty models. 14) Competing Joint Frailty Model: A single type of recurrent event and two terminal events. 15) functions to compute power and sample size for four Gamma-frailty-based designs: Shared Frailty Models, Nested Frailty Models, Joint Frailty Models, and General Joint Frailty Models. Each design includes two primary functions: a power function, which computes power given a specified sample size; and a sample size function, which computes the required sample size to achieve a specified power. 16) Weibull Illness-Death model with or without shared frailty between transitions. Left-truncated and right-censored data are allowed. 17) Weibull Competing risks model with or without shared frailty between the transitions. Left-truncated and right-censored data are allowed. Moreover, the package can be used with its shiny application, in a local mode or by following the link below.
- Copula.surv
- Statistical modelling of survival data with random effects. H-likelihood approach
- survival
- mstate
- Multivariate frailty models for multi-type recurrent event data and its application to cancer prevention trial
- Posterior consistency in frailty models and simulation studies to test the presence of random effects
- aster
- eha
- Statmod
- Choice of time scale for analysis of recurrent events data
- MKVPCI
- Accelerated failure time models for recurrent event data analysis and joint modeling
- An additive hazards frailty model with semi-varying coefficients
- JM
- Modeling marginal features in studies of recurrent events in the presence of a terminal event
- invGauss
- Generalized frailty models for analysis of recurrent events
- addreg
- lcmm
- coxph
- PATSYM
- HRMSYM
- CopulaRegression
- SmoothHazard
- relsurv
- JMfit
- mdhglm
- joint.Cox
- pec
- DStree
- Dynamical biostatistical models
- gamboostMSM
- Joint model for left-censored longitudinal data, recurrent events and terminal event: predictive abilities of tumor burden for cancer evolution with application to the FFCD 2000--05 trial
- Correlated versus uncorrelated frailty Cox models: a comparison of different estimation procedures
- Joint frailty models for recurring events and death using maximum penalized likelihood estimation: application on cancer events
- Multivariate frailty models for two types of recurrent events with a dependent terminal event: application to breast cancer data
- Smoothing spline ANOVA frailty model for recurrent event data
- Time-varying coefficients in a multivariate frailty model: application to breast cancer recurrences of several types and death
- Analysis of multivariate recurrent event data with time-dependent covariates and informative censoring
- surrosurv
- frailtySurv
- frailtyHL
- phmm
- Ryacas
- survsim
- parfm
- MST
- coxme
- joineRML
- frailtyEM
- Testing independence between two sequential gap times in the presence of covariates
- JMbayes
- STJM
- joineR
- frailtyGAFT
- TPmsm
- SMM
- msSurv
- SemiMarkov
- tdc.msm
- Analysis of Longitudinal Data in the Presence of Informative Observational Times and a Dependent Terminal Event, with Application to Medical Cost Data
- Semiparametric analysis for recurrent event data with time-dependent covariates and informative censoring
- stgenreg
- PermAlgo
- JM SAS
- crrSC
- hrIPW
- PHMPL
- tram
- JSM
- Frailty modelling of time-to-lapse of single policies for customers holding multiple car contracts
- merlin
- Estimation for frailty measurement error Cox models based on profile likelihood and Bayes methods
- Comparing crossing hazard rate functions by joint modelling of survival and longitudinal data
- Frailty modelling for multitype recurrent events in clinical trials
- A marginalized combined gamma frailty and normal random-effects model for repeated, overdispersed, time-to-event outcomes
- Two-stage estimation for multivariate recurrent event data with a dependent terminal event
- streg
- Data Analysis Using Hierarchical Generalized Linear Models With R
- reReg
- stcox
- stpm2
- mexhaz
- strcs
- joineRmeta
- Joint analysis of recurrent event data with additive-multiplicative hazards model for the terminal event time
- PDXpower
- frailtyROC
- Joint covariate-adjusted score test statistics for recurrent events and a terminal event
- Semiparametric analysis of panel count data with correlated observation and follow-up times
- Nonparametric modeling of the gap time in recurrent event data
- Joint analysis of current count and current status data
- Variable selection in discrete survival models including heterogeneity
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