frailtypack (Q18208)

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Shared, Joint (Generalized) Frailty Models; Surrogate Endpoints
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frailtypack
Shared, Joint (Generalized) Frailty Models; Surrogate Endpoints

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    3.5.0
    20 December 2021
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    0.8-1
    22 February 2005
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    0.8-2
    22 February 2005
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    1.0-0
    26 March 2005
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    2.0-0
    30 May 2005
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    2.0-1
    18 November 2005
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    2.0-2
    21 November 2005
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    2.1-1
    28 July 2008
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    2.2-9.5
    23 October 2009
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    2.2-12
    11 January 2010
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    2.2-13
    1 May 2010
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    2.2-14
    18 May 2010
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    2.2-16
    13 October 2010
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    2.2-17
    3 August 2011
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    2.2-18
    1 September 2011
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    2.2-19
    24 October 2011
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    2.2-20
    26 October 2011
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    2.2-21
    6 February 2012
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    2.2-22
    13 March 2012
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    2.2-23
    5 April 2012
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    2.2-24
    25 July 2012
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    2.2-25
    6 September 2012
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    2.2-26
    19 October 2012
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    2.2-27
    27 November 2012
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    2.3
    9 February 2013
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    2.4.1
    26 April 2013
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    2.4
    5 April 2013
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    2.5.1
    13 February 2014
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    2.5
    20 November 2013
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    2.6.1
    23 July 2014
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    2.6
    24 March 2014
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    2.7.1
    8 October 2014
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    2.7.2
    16 October 2014
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    2.7.4
    26 February 2015
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    2.7.5
    6 March 2015
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    2.7.6.1
    1 September 2015
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    2.7
    30 August 2014
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    2.8.1
    21 November 2015
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    2.8.2
    9 December 2015
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    2.8.3
    13 January 2016
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    2.9.3.1
    8 July 2016
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    2.9.3
    7 July 2016
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    2.9.4
    25 July 2016
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    2.10.3
    19 October 2016
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    2.10.4
    4 January 2017
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    2.10.5
    3 February 2017
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    2.10.6
    7 March 2017
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    2.11.0
    11 March 2017
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    2.11.1
    21 March 2017
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    2.12.1
    16 June 2017
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    2.12.2
    9 July 2017
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    2.12.3
    1 August 2017
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    2.12.4
    1 September 2017
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    2.12.5
    21 September 2017
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    2.12.6
    6 October 2017
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    2.12.7
    30 July 2018
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    2.13.1
    17 September 2018
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    2.13.2
    25 September 2018
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    3.0.1
    26 November 2018
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    3.0.2.1
    7 January 2019
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    3.0.2
    10 December 2018
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    3.0.3.1
    4 March 2019
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    3.0.3.2.1
    30 October 2019
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    3.0.3.2
    16 May 2019
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    3.1.0
    16 January 2020
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    3.2.0.1
    27 May 2020
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    3.2.0
    12 April 2020
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    3.3.0
    15 June 2020
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    3.3.2
    14 October 2020
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    3.4.0
    16 June 2021
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    3.5.1
    25 November 2023
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    25 November 2023
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    The following several classes of frailty models using a penalized likelihood estimation on the hazard function but also a parametric estimation can be fit using this R package: 1) A shared frailty model (with gamma or log-normal frailty distribution) and Cox proportional hazard model. Clustered and recurrent survival times can be studied. 2) Additive frailty models for proportional hazard models with two correlated random effects (intercept random effect with random slope). 3) Nested frailty models for hierarchically clustered data (with 2 levels of clustering) by including two iid gamma random effects. 4) Joint frailty models in the context of the joint modelling for recurrent events with terminal event for clustered data or not. A joint frailty model for two semi-competing risks and clustered data is also proposed.5) Joint general frailty models in the context of the joint modelling for recurrent events with terminal event data with two independent frailty terms.6) Joint Nested frailty models in the context of the joint modelling for recurrent events with terminal event, for hierarchically clustered data (with two levels of clustering) by including two iid gamma random effects.7) Multivariate joint frailty models for two types of recurrent events and a terminal event.8) Joint models for longitudinal data and a terminal event.9) Trivariate joint models for longitudinal data, recurrent events and a terminal event.10) Joint frailty models for the validation of surrogate endpoints in multiple randomized clinical trials with failure-time endpointswith the possibility to use a mediation analysis model. 11) Conditional and Marginal two-part joint models for longitudinal semicontinuous data and a terminal event. 12) Joint frailty-copula models for the validation of surrogate endpoints in multiple randomized clinical trials with failure-time endpoints.13) Generalized shared and joint frailty models for recurrent and terminal events. Proportional hazards (PH), additive hazard (AH), proportional odds (PO) and probit models are available in a fully parametric framework. For PH and AH models, it is possible to consider type-varying coefficients and flexible semiparametric hazard function.Prediction values are available (for a terminal event or for a new recurrent event). Left-truncated (not for Joint model), right-censored data, interval-censored data (only for Cox proportional hazard and shared frailty model) and strata are allowed. In each model, the random effects have the gamma or normal distribution. Now, you can also consider time-varying covariates effects in Cox, shared and joint frailty models (1-5). The package includes concordance measures for Cox proportional hazards models and for shared frailty models.Moreover, the package can be used with its shiny application, in a local mode or by following the link below.
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