Gatekeeping testing via adaptive alpha allocation

DOI10.1002/BIMJ.200710450MaRDI QIDQ5123106zbMATH OpenOpenAlexWikidataFDO

Authors Jianjun Li, Devan V. Mehrotra

Publication date 25 September 2020

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.200710450

zbMATH Keywords

\(p\)-valueclinical trialsfamilywise error ratemultiple tests: gatekeeping

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• A simple and flexible Holm gatekeeping procedure
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Cited in

(8)

• Development of gatekeeping strategies in confirmatory clinical trials
• Testing for efficacy in primary and secondary endpoints by partitioning decision paths
• A simple and flexible Holm gatekeeping procedure
• A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks
• A multiple comparison procedure for hypotheses with gatekeeping structure
• A Note on Familywise Error Rate for a Primary and Secondary Endpoint
• Advanced multiplicity adjustment methods in clinical trials
• Extension of adaptive alpha allocation methods for strong control of the family-wise error rate

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