Generalized sensitivity functions for size-structured population models

DOI10.1515/JIIP-2014-0041MaRDI QIDQ299019zbMATH OpenOpenAlexFDO

Authors Dustin D. Keck, David M. Bortz

Publication date 22 June 2016

Published in Journal of Inverse and Ill-posed Problems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1406.0212

zbMATH Keywords

generalized sensitivitysize-structured population modelSmoluchowski coagulation equation

Mathematics Subject Classification ID

Population dynamics (general) (92D25) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Abstract: Size-structured population models provide a popular means to mathematically describe phenomena such as bacterial aggregation, schooling fish, and planetesimal evolution. For parameter estimation, generalized sensitivity functions (GSFs) provide a tool that quantifies the impact of data from specific regions of the experimental domain. These functions help identify the most relevant data subdomains, which enhances the optimization of experimental design. To our knowledge, GSFs have not been used in the partial differential equation (PDE) realm, so we provide a novel PDE extension of the discrete and continuous ordinary differential equation (ODE) concepts of Thomaseth and Cobelli and Banks et al. respectively. We analyze the GSFs in the context of size-structured population models, and specifically analyze the Smoluchowski coagulation equation to determine the most relevant time and volume domains for three, distinct aggregation kernels. Finally, we provide evidence that parameter estimation for the Smoluchowski coagulation equation does not require post-gelation data.

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Cited in

(4)

• Weak SINDy for partial differential equations
• Generalized sensitivity functions for multiple output systems
• Sensitivity and elasticity of density-dependent population models
• Direct estimation of parameters in ODE models using WENDy: weak-form estimation of nonlinear dynamics

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