grantham

Authors Ramiro Magno, Isabel Duarte, Ana Teresa Maia

Last update 31 May 2025

Copyright license MIT license, File License

Software version identifier 0.1.1, PACKAGES.rds, 0.1.0, 0.1.2, 0.1.3, 0.1.4

Description

A minimal set of routines to calculate the Grantham distance <doi:10.1126/science.185.4154.862>. The Grantham distance attempts to provide a proxy for the evolutionary distance between two amino acids based on three key chemical properties: composition, polarity and molecular volume. In turn, evolutionary distance is used as a proxy for the impact of missense mutations. The higher the distance, the more deleterious the substitution is expected to be.

Cites work

Amino Acid Difference Formula to Help Explain Protein Evolution

Cited in

(1)

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