grantham (Q97014)
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Calculate the Grantham Distance
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | No label defined |
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| English | grantham |
Calculate the Grantham Distance |
Statements
31 May 2025
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A minimal set of routines to calculate the Grantham distance <doi:10.1126/science.185.4154.862>. The Grantham distance attempts to provide a proxy for the evolutionary distance between two amino acids based on three key chemical properties: composition, polarity and molecular volume. In turn, evolutionary distance is used as a proxy for the impact of missense mutations. The higher the distance, the more deleterious the substitution is expected to be.
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