gsDesign2

Authors Jianxiao Yang, Keaven Anderson, Yilong Zhang, Nan Xiao, Yujie Zhao

Last update 9 February 2024

Copyright license GNU General Public License, version 3.0

Software version identifier 1.0.7, 1.0.8, 1.0.9, 1.1.0, 1.1.1

The goal of 'gsDesign2' is to enable fixed or group sequential design under non-proportional hazards. To enable highly flexible enrollment, time-to-event and time-to-dropout assumptions, 'gsDesign2' offers piecewise constant enrollment, failure rates, and dropout rates for a stratified population. This package includes three methods for designs: average hazard ratio, weighted logrank tests in Yung and Liu (2019) <doi:10.1111/biom.13196>, and MaxCombo tests. Substantial flexibility on top of what is in the 'gsDesign' package is intended for selecting boundaries.

Cites work

Sample size and power for the weighted log‐rank test and Kaplan‐Meier based tests with allowance for nonproportional hazards

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