Inferring average generation via division-linked labeling

DOI10.1007/S00285-015-0963-3MaRDI QIDQ304054zbMATH OpenOpenAlexWikidataFDO

Authors Tom S. Weber, Leïla Perié, Ken R. Duffy

Publication date 23 August 2016

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1506.02286

zbMATH Keywords

branching processesaverage generation inferencestochastically decorated trees

Mathematics Subject Classification ID

Applications of branching processes (60J85) Cell biology (92C37)

Abstract: For proliferating cells subject to both division and death, how can one estimate the average generation number of the living population without continuous observation or a division-diluting dye? In this paper we provide a method for cell systems such that at each division there is an unlikely, heritable one-way label change that has no impact other than to serve as a distinguishing marker. If the probability of label change per cell generation can be determined and the proportion of labeled cells at a given time point can be measured, we establish that the average generation number of living cells can be estimated. Crucially, the estimator does not depend on knowledge of the statistics of cell cycle, death rates or total cell numbers. We validate the estimator and illustrate its features through comparison with published data and physiologically parameterized stochastic simulations, using it to suggest new experimental designs.

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Cited in

(3)

• The variance of the average depth of a pure birth process converges to 7
• Approximations for Expected Generation Number
• Sample path properties of the average generation of a Bellman-Harris process

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