Inferring network structure from interventional time-course experiments
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Abstract: Graphical models are widely used to study biological networks. Interventions on network nodes are an important feature of many experimental designs for the study of biological networks. In this paper we put forward a causal variant of dynamic Bayesian networks (DBNs) for the purpose of modeling time-course data with interventions. The models inherit the simplicity and computational efficiency of DBNs but allow interventional data to be integrated into network inference. We show empirical results, on both simulated and experimental data, that demonstrate the need to appropriately handle interventions when interventions form part of the design.
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Cites work
- scientific article; zbMATH DE number 1493045 (Why is no real title available?)
- Bayes and empirical-Bayes multiplicity adjustment in the variable-selection problem
- Causal inference in statistics: an overview
- Estimating high-dimensional intervention effects from observational data
- Experiment selection for causal discovery
- External validity: from do-calculus to transportability across populations
- Inferring network structure from interventional time-course experiments
- Network inference and biological dynamics
- Nonparametric regression using Bayesian variable selection
- Reconstructing Gene Regulatory Networks with Bayesian Networks by Combining Expression Data with Multiple Sources of Prior Knowledge
Cited in
(5)- Objective Bayes model selection of Gaussian interventional essential graphs for the identification of signaling pathways
- Network enrichment analysis in complex experiments
- Designs for estimating the treatment effect in networks with interference
- Improved baselines for causal structure learning on interventional data
- Inferring network structure from interventional time-course experiments
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