Conformational changes in the connector protein complex of the bacteriophage \(\varphi 29\) DNA packaging motor (Q1001567)
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scientific article; zbMATH DE number 5508961
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| English | Conformational changes in the connector protein complex of the bacteriophage \(\varphi 29\) DNA packaging motor |
scientific article; zbMATH DE number 5508961 |
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Conformational changes in the connector protein complex of the bacteriophage \(\varphi 29\) DNA packaging motor (English)
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18 February 2009
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Summary: DNA packaging in the bacteriophage \(\varphi 29\) involves a molecular motor. It is proposed that dsDNA is packaged through a channel in a connector located at the 5-fold vertex of a preformed prolate icosahedral capsid. The packaging motor also consists of virally-encoded RNA molecules (pRNA) coupled to ATPases. Data obtained from studies using surface plasmon resonance, fluorescence quenching and circular dichroism are presented to demonstrate the importance of the N-termini of the connector protein subunits in pRNA interactions and in conformational change. Based on our findings, we propose a model of DNA packaging based on connector conformational change.
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RNA-protein interaction
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bacteriophage \(\varphi 29\)
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molecular motor
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virus assembly
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conformational change
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0.7880688309669495
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0.7276366353034973
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0.7145217657089233
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0.6804760694503784
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