Effect of heterogeneous oxygen delivery on the oxygen distribution in skeletal muscle (Q1080788)

Calculations of the oxygen distribution in resting and contracting skeletal muscle are presented, based on a mathematical model and experimental data obtained on the hamster cremaster musle [\textit{B. Klitzman}, the first author and \textit{B. R. Duling}, Microvasc. Res. 25, 108-131 (1983)]. The model considers a slab of tissue penetrated by a regular square array of capillaries with concurrent flow. The intracapillary resistance to oxygen transport is neglected. The capillary red blood cell flux and capillary inlet oxygen tension are assumed random variables following certain probability distributions. The sensitivity of the tissue and intracapillary \(PO_ 2\) to variations of these probability distributions are investigated. The mean tissue \(PO_ 2\) decreases as the dispersion of the random variables increases, provided that their mean values remain constant. Hypoxic regions appear gradually, especially in the case of contracting muscle, as the dispersion increases. The effect of the number of capillaries in the sample on the resultant distribution of oxygen is studied systematically. The calculated tissue \(PO_ 2\) histograms are compared with previously reported \(PO_ 2\) distributions obtained experimentally for resting and contracting skeletal muscles.