The transient solution of the linear birth-death process with random spontaneous mutation (Q1082281)
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| Language | Label | Description | Also known as |
|---|---|---|---|
| English | The transient solution of the linear birth-death process with random spontaneous mutation |
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The transient solution of the linear birth-death process with random spontaneous mutation (English)
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1986
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The transient solution of the simple linear birth-death process subject to random mutation is derived. The solution is applied to investigate the curability of cancer under drug treatment. Tumor cells are assumed to proliferate by division, and may die or be lost to the population. Mutation is from drug sensitivity to resistance, and may occur only at division. Expressions are derived relating curability of the disease to increasing tumor size, and to the delay before treatment is given.
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cancer therapy
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chemotherapy
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transient solution
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linear birth-death process
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random mutation
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curability of cancer under drug treatment
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tumor size
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