Optimal control of the immune response synchronizing the various regulatory compartments of the immune system. II. Identification of model parameters and missing data recovery (Q1264620)

Individual treatment is one of the central problems in modern medicine. Increasing computerization of medicine may help solve this problem by providing quantitative approaches to the assessment of the state of the patient's organism. The increasing level of intelligence of modern computers, software, and technical tools make it possible to move gradually toward the development of individualized patient models and individualized optimal treatment. The present article focuses on one aspect of this problem, specifically identification of the parameters of the individualized patient model and recovery of missing data. We apply the method of missing data recovery using the dynamic models of part I of this paper, ibid. 31, No. 2, 225-239 (1995; Zbl 0837.92010), with databases of clinical-immunological characteristics of patients with hemoblastosis and preleucosis.