On using index cases in the study of late-onset diseases (Q1304082)
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scientific article; zbMATH DE number 1348350
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| English | On using index cases in the study of late-onset diseases |
scientific article; zbMATH DE number 1348350 |
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On using index cases in the study of late-onset diseases (English)
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5 October 1999
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The method of index cases is used to construct a nonparametric estimator for the average cumulative risk of a late-onset disease in a population, under censoring, which is consistent even if the risk is suspected to vary with the individual in an unknown manner. In contrast, illustrations show the need for caution when index cases are used for testing whether a disease is familial.
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Kaplan-meier estimator
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familial disease
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BRCA1
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BRCA2
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index cases
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late-onset disease
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0.7842642068862915
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0.7666882872581482
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0.7049658894538879
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