An unbiased test for the bioequivalence problem (Q1383083)
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scientific article; zbMATH DE number 1138415
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| English | An unbiased test for the bioequivalence problem |
scientific article; zbMATH DE number 1138415 |
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An unbiased test for the bioequivalence problem (English)
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25 May 1998
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The authors treat the problem demonstrating bioequivalence of treatments. The standard two one-sided tests procedure for bioequivalence is biased, so they construct an unbiased \(\alpha\)-level test. Since, in the construction, the rejection region of the unbiased test contains that of the two one-sided tests procedure, it is seen that the unbiased test is uniformly more powerful than the \(\alpha\)-level two-sided test procedure. The construction is numerically complemented and also the critical region is illustrated.
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uniformly most powerful
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pharmacokinetic parameters
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two one-sided tests procedure
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unbiased \(\alpha\)-level test
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0.9135982394218444
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0.8625882267951965
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0.8597240447998047
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