A new unsteady three-dimensional model for macromolecular transport and water filtration across the arterial wall. (Q1596404)

An unsteady three-dimensional time-dependent convective-diffusive mathematical model for the transportation of macromolecules and water across the arterial wall has been proposed. The model numerically simulates the macromolecular accumulation with the time. A complete transport model for the whole arterial wall has been built up by relating the different layers -- the endothelial layer, the subendothelial intima, the internal elastic lamina and the media -- with interface conditions. The analytical solutions for the velocity and pressure of water flow across the arterial wall have been presented. The concentration distribution of macromolecules LDL, HRP and albumin have been numerically simulated. The results show that the concentration reaches its peak at the leaky junction where atherosclerotic formation frequently occurs and falls down rapidly in a limited area. The predictions of the model have been found to be in good agreement with experimental observations for growth and concentration distribution of LDL and albumin.