Computational prediction of the combined effect of CRT and LVAD on cardiac electromechanical delay in LBBB and RBBB (Q1728810)

Summary: Two case reports showed that the combination of cardiac resynchronization therapy (CRT) and left ventricular assist device (LVAD) benefits the end-stage heart failure patients with prolonged QRS interval significantly. In one of the reports, the patient had the LVAD removed due to the recovery of the heart function. However, the quantification of the combined devices has yet to be conducted. This study aimed at computationally predicting the effects of CRT-only or combined with LVAD on electromechanical behaviour in the failing ventricle with left bundle branch blocked (LBBB) and right bundle branch blocked (RBBB) conditions. The subjects are normal sinus rhythm, LBBB, RBBB, LBBB with CRT-only, RBBB with CRT-only, LBBB with CRT + LVAD, and RBBB with CRT + LVAD. The results showed that the CRT-only shortened the total electrical activation time (EAT) in the LBBB and RBBB conditions by 20.2\% and 17.1\%, respectively. The CRT-only reduced the total mechanical activation time (MAT) and electromechanical delay (EMD) of the ventricle under LBBB by 21.3\% and 10.1\%, respectively. Furthermore, the CRT-only reduced the contractile adenosine triphosphate (ATP) consumption by 5\%, increased left ventricular (LV) pressure by 6\%, and enhanced cardiac output (CO) by 0.2~L/min under LBBB condition. However, CRT-only barely affects the ventricle under RBBB condition. Under the LBBB condition, CRT + LVAD increased LV pressure and CO by 10.5\% and by 0.9~L/min, respectively. CRT + LVAD reduced ATP consumption by 15\%, shortened the MAT by 23.4\%, and shortened the EMD by 15.2\%. In conclusion, we computationally predicted and quantified that the CRT + LVAD implementation is superior to CRT-only implementation particularly in HF with LBBB condition.