Global stability of a SLIT TB model with staged progression (Q1760746)

Summary: Because the latent period and the infectious period of tuberculosis (TB) are very long, it is not reasonable to consider the time as constant. So this paper formulates a mathematical model that divides the latent period and the infectious period into \(n\)-stages. For a general \(n\)-stage stage progression (SP) model with bilinear incidence, we analyze its dynamic behavior. First, we give the basic reproduction number \(R_0\). Moreover, if \(R_0 \leq 1\), the disease-free equilibrium \(P_0\) is globally asymptotically stable and the disease always dies out. If \(R_0 > 1 \), the unique endemic equilibrium \(P^\ast\) is globally asymptotically stable and the disease persists at the endemic equilibrium.