Fast and slow dynamics of malaria and the \(S\)-gene frequency (Q1763016)

The paper is devoted to the study of a model describing both malaria epidemics and human population genetics of the sickle cell. The authors rewrite the system in a singularly perturbed form, and use the singular perturbation techniques to separate the dynamics of the system. The slow manifold is constructed and the dynamics of the system on the slow manifold is investigated. The analysis of the model provides insights how malaria epidemics may have an impact on the maintenance of the sickle cell gene in a population, where malaria is prevalent.