The effects of control domain position on optimal control of cardiac arrhythmia (Q1952857)

Summary: We study the effects of control domain position on the optimal control problem of cardiac arrhythmia. A well-established mathematical model, namely, the monodomain model, is used to represent the electrical behavior of cardiac tissues. Two test cases are considered: the control domain for test case 1 is close to the excitation domain, while the control domain for test case 2 is a little bit far away from the excitation domain. The modified \textit{Y.H. Dai} and \textit{Y. Yuan} [SIAM J. OPTIM 10, No. 1, 177--182 (1999; Zbl 0957.65061)] nonlinear conjugate gradient method is employed for computing the optimal applied extracellular currents. Our experimental results show that the excitation wavefronts are successfully dampened out for both test cases. Also, the experimental results show that the position of the control domain for test case 1 is preferable than that of test case 2 during the defibrillation process.