Modelling and analysis of HFMD with the effects of vaccination, contaminated environments and quarantine in mainland China (Q2160585)

This paper proposed a hand, foot and mouth disease (HFMD) model with vaccination, contaminated environment, and quarantine. The main purpose of the paper is to show the disease is extinct or persistent based on basic reproduction ratio \(R_0\), such threshold was obtained by using the next generation matrix method. At last, the sensitivity analyses and numerical experiments show that increasing the rate of virus clearance, the vaccinated rate of infants and young children, and the quarantined rate of infectious individuals can effectively control the spread of HFMD in mainland China.