Modelling the dynamics of LCMV infection in mice. II: Compartmental structure and immunopathology (Q2177125)

The authors develop an immunopathology of lymphocytic choriomeningitis virus infection model in mice and analyze the dynamics of the LCMV infection model. The modelling analysis suggests that quantitative demands to CTL memory for maximal protection against a wide range of doses of infection with a primarilyperipher al site of virus replication without the risk of favoring immunopathology. It specifies objectives for CTL vaccination to ensure virus elimination with minimal immunopathology vs. vaccination for disease.