Stability analysis and clinic phenomenon simulation of a fractional-order HBV infection model (Q2210288)

Summary: In this paper, a fractional-order HBV model was set up based on standard mass action incidences and quasisteady assumption. The basic reproductive number \(R_0\) and the cytotoxic T lymphocytes' immune-response reproductive number \(R_1\) were derived. There were three equilibrium points of the model, and stable analysis of each equilibrium point was given with corresponding hypothesis about \(R_0\) or \(R_1\). Some numerical simulations were also given based on HBeAg clinical data, and the simulation showed that there existed positive logarithmic correlation between the number of infected cells and HBeAg, which was consistent with the clinical facts. The simulation also showed that the clinical individual differences should be reflected by the fractional-order model.