On a phase field model of Cahn-Hilliard type for tumour growth with mechanical effects (Q2215483)
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| English | On a phase field model of Cahn-Hilliard type for tumour growth with mechanical effects |
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On a phase field model of Cahn-Hilliard type for tumour growth with mechanical effects (English)
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13 December 2020
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This article presents a Cahn-Hilliard model of tumor growth which exhibits mechanical effects due to cell-cell adhesion. The authors consider a Cahn-Hilliard variant (e.g. cf. [\textit{A. Miranville}, The Cahn-Hilliard equation. Recent advances and applications. Philadelphia, PA: Society for Industrial and Applied Mathematics (SIAM) (2019; Zbl 1446.35001)]) coupled to a system of equations of linear elasticity, which communicates the proliferation rate, and a reaction-diffusion equation which describes nutrient concentration. Well-possdness results are obtained as well as various continuous dependence estimates for different topologies. The results here are important because of the difficulties that arise from the nonlinear coupling of the fourth-order Cahn-Hilliard equation and the quasi-static elasticity system.
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tumour growth
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Cahn-Hilliard equation
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mechanical effects
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linear elasticity
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elliptic-parabolic system
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existence and uniqueness
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