Parameters identification and optimal control in pharmacokinetics (Q2265970)

The authors examine a method of determining kinetic parameters in linear compartment models of the form \(X'=AX\) where the characteristic values of A are distinct (a condition not recognized in the paper). Utilizing numerically determined estimates of the characteristic values of A [presented in \textit{Y. Cherruault}, Biomathématiques, P.U.F., Collection Que Sais-Je (1983)], and supplementing the system with algebraic equations involving initial values of the \(X_ i\) and their derivatives, they are able to circumvent potential problems involved with observability. In cases where non-uniqueness of the computed parameters results, the authors suggest adjoining a minimization criteria involving a measure of the ''fitness'' of the model.