Nonparametric false discovery rate control for identifying simultaneous signals (Q2286361)

This paper studies the problem of identifying features that are non-null in each of several experiments under false discovery rate control. A nonparametric false discovery rate control procedure that can identify such simultaneous signals even without knowing the null distributions is proposed. The method is shown, theoretically and in simulations, to asymptotically control the false discovery rate. It was also used to identify genes that were both differentially expressed and proximal to differentially accessible chromatin in the brains of mice exposed to a conspecific intruder. The method is made available in an R package.