Innovative approximate analytical solution for standard model of viral dynamics: hepatitis C with direct-acting agents as an implemented case (Q2298065)

Summary: In this article, a novel approximate analytical solution is presented for solving the standard viral dynamic model. Basically, the standard model is used to study viral dynamics in patients for a wide range of viruses like HIV, HPV, HBV, and HCV. In this research work, the standard model for hepatitis C virus (HCV) is considered in detail; however, the analysis and results can be applicable for all other viruses. This standard model is used to study viral dynamics in patients treated with direct-acting antiviral agents (DAAs). Power series solution combined with Laplace-Padé resummation method (PSLP) is used to obtain the approximate analytical solutions for the model. To test the capability as well as the validity of the proposed method, results are compared with available viral load data published in the literature and with published simulation results. Good fits are obtained in the comparison for all cases considered. Given that medical specialists and physicians are more interested in solutions that yield direct and simple predictions, it is expected that the proposed approximate analytical solution would be attractive to them and help them to obtain a straightforward and a proper estimation regarding the viral load due to variations in treatment and/or patient's parameters.