A hybrid model for the effects of treatment and demography on malaria superinfection (Q2308861)

This paper studies a hybrid model for the effects of treatment and demography on malaria superinfection. The work starts with modeling and analysis of a system with demography and treatment but without chemoprotection. For a Poisson process \(x\) of new infections in an individual person with intensity \(\lambda\) as the force of infection. Let \(\mu\) be the sum of the mean death-birth rate and the mean treatment rate. The treatment and demographic process can be described as \(dx_0/dt=-\lambda x_0+r x_1+\mu(1-x_0)\) and \(dx_n/dt=\lambda x_{n-1}+r(n+1)x_{n+1}-(\lambda+rn+\mu)x_n\) with \(r\) being a recovery rate coefficient. Expected prevalence and stability distribution have been derived. Then it is assumed that once a person is treated they enter a protected state for a mean of \(\omega^{-1}\) units of time before they go back to a susceptible state. In this model with chemoprotection, a pseudo-equilibrium analysis is performed. The paper also couples the human system with a vector system to examine the transmission dynamics. Strong assumptions of the Ross-Macdonald model with superinfection of no demographic turnover and no treatment have been relaxed.