Effect of treatment on the global dynamics of delayed pathological angiogenesis models (Q2341145)

In this paper are presented three delayed models of pathological angiogenesis: cancer-induced angiogenesis with a Gompertz tumor growth, cancer-induced and vascular-induced angiogenesis with a continuous tumor growth. Model 1 is a particular case of the model 3. There is an additional difference between the models, with continuous and impulsive treatment, defined by two special conditions. The dynamics of model 1 are explored under continuous therapy, and the models 2 and 3 under impulse therapy. The latter means short-time treatment with a duration negligible compared to the process time. Theorem 2.1 provides for model 1 sufficient conditions for cancer eradication, and gives estimates of the exponential decay of tumor volume and vasculature. Because of ``the delayed nature of the model, the estimates for the vascular decay involve the maximal delay as a parameter and thus are appropriate for variable but bounded delay only.'' Another additional two factors included in estimates are the frequency and the intensity of impulsive treatment. This is the authors' original consideration for the angiogenesis models. As a conclusion, five open problems related to the results of the paper are listed.