Dynamics analysis of an HIV infection model including infected cells in an eclipse stage (Q2375539)

Summary: An HIV infection model including an eclipse stage of infected cells is considered. Some quicker cells in this stage become productively infected cells, and a portion of these cells is reverted to the uninfected class, and the others will be latent in the body. We consider the cytotoxic T lymphocytes (CTL)-response delay in this model and analyze the effect of time delays on the stability of the equilibrium. It is shown that the uninfected equilibrium and CTL-absent infection equilibrium are globally asymptotically stable for both the ODE and delay differential equations (DDE) model. And we get the global stability of the CTL-present equilibrium for the ODE model. For the DDE model, we have proved that the CTL-present equilibrium is locally asymptotically stable in a range of delays and have also studied the existence of Hopf bifurcations at the CTL-present equilibrium. Numerical simulations are carried out to support our main results.