topologyGSA (Q27071)
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Gene Set Analysis Exploiting Pathway Topology
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | No label defined |
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| English | topologyGSA |
Gene Set Analysis Exploiting Pathway Topology |
Statements
25 September 2023
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Using Gaussian graphical models we propose a novel approach to perform pathway analysis using gene expression. Given the structure of a graph (a pathway) we introduce two statistical tests to compare the mean and the concentration matrices between two groups. Specifically, these tests can be performed on the graph and on its connected components (cliques). The package is based on the method described in Massa M.S., Chiogna M., Romualdi C. (2010) <doi:10.1186/1752-0509-4-121>.
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