shazam (Q28011)
From MaRDI portal
Immunoglobulin Somatic Hypermutation Analysis
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | shazam |
Immunoglobulin Somatic Hypermutation Analysis |
Statements
2 October 2023
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Provides a computational framework for analyzing mutations in immunoglobulin (Ig) sequences. Includes methods for Bayesian estimation of antigen-driven selection pressure, mutational load quantification, building of somatic hypermutation (SHM) models, and model-dependent distance calculations. Also includes empirically derived models of SHM for both mice and humans. Citations: Gupta and Vander Heiden, et al (2015) <doi:10.1093/bioinformatics/btv359>, Yaari, et al (2012) <doi:10.1093/nar/gks457>, Yaari, et al (2013) <doi:10.3389/fimmu.2013.00358>, Cui, et al (2016) <doi:10.4049/jimmunol.1502263>.
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