Comb-like models for transport along spiny dendrites (Q280305)

The authors propose a modified comb model to describe anomalous transport in spiny dendrites. Geometry of the comb structure consisting of a one-dimensional backbone and lateral branches makes it possible to describe anomalous diffusion, where dynamics inside fingers corresponds to spines, while the backbone describes diffusion along dendrites. The new model is based on fractional dynamics in spiny dendrites, and is controlled by fractal geometry of the comb structure and fractional kinetics inside the spines. The result shows that the transport along spiny dendrites is sub-diffusive and depends on the density of spines.